T-cell marker - translation to Αγγλικά
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T-cell marker - translation to Αγγλικά

MOLECULE FOUND ON THE SURFACE OF SOME IMMUNE CELLS
Alpha-beta T-cell antigen receptor; Genes, t-cell receptor; T-cell receptors; Receptors, antigen, t-cell; T-cell antigen receptors; TCRδ1; TCRd1; T cell receptor

T-cell marker      

общая лексика

T-клеточный маркёр

T-cell receptor         

медицина

рецептор Т-клетки

T-lymphocyte         
TYPE OF LYMPHOCYTE
T-cell; T lymphocyte; T cells; T-lymphocytes; T lymphocytes; T Lymphocyte; T-cells; T-Cell; T-lymphocyte; T-lymphocyte subsets; T-Cells; Differential avidity hypothesis; T Lymphocytes; T cell activation; T cell tolerance; Avidity hypothesis; Differential signaling hypothesis; Differential Avidity Hypothesis; Differential Signaling Hypothesis; T Cell; T Cells; Double-negative T cell; Effector T cell; T-Cell Activation in Space; T-cell activation; T-cell exhaustion; Exhausted T cell; Lymphocyte T; Effector T Cell; T cell exhaustion; Differential signalling hypothesis; Differential Signalling Hypothesis; Unconventional T cells; Innate-like T cell

медицина

Т-лимфоцит

Ορισμός

т
Т, согласная буква те, твердо, 19-я в азбуке (в церк. 20-я); в церковном счислении: Т триста, триста тысяч, в круге, и в точках, см. А
. ·сокр. т. е., то есть; т. к., так как; и т. д. и так далее; и т. п., и тому подобное; т., том; тысяч.

Βικιπαίδεια

T-cell receptor

The T-cell receptor (TCR) is a protein complex found on the surface of T cells, or T lymphocytes, that is responsible for recognizing fragments of antigen as peptides bound to major histocompatibility complex (MHC) molecules. The binding between TCR and antigen peptides is of relatively low affinity and is degenerate: that is, many TCRs recognize the same antigen peptide and many antigen peptides are recognized by the same TCR.

The TCR is composed of two different protein chains (that is, it is a heterodimer). In humans, in 95% of T cells the TCR consists of an alpha (α) chain and a beta (β) chain (encoded by TRA and TRB, respectively), whereas in 5% of T cells the TCR consists of gamma and delta (γ/δ) chains (encoded by TRG and TRD, respectively). This ratio changes during ontogeny and in diseased states (such as leukemia). It also differs between species. Orthologues of the 4 loci have been mapped in various species. Each locus can produce a variety of polypeptides with constant and variable regions.

When the TCR engages with antigenic peptide and MHC (peptide/MHC), the T lymphocyte is activated through signal transduction, that is, a series of biochemical events mediated by associated enzymes, co-receptors, specialized adaptor molecules, and activated or released transcription factors. Based on the initial receptor triggering mechanism, the TCR belongs to the family of non-catalytic tyrosine-phosphorylated receptors (NTRs).

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